Following a lone-game homestand, the Chicago Bulls are set to begin their four-game road trip with the first stop in Michigan. Wednesday’s contest against the Detroit Pistons marks their second of four meetings between the teams in the 2025-2026 regular season.
**Chicago Bulls vs. Detroit Pistons Preview, Odds, Betting Tips, and Prediction**
The Bulls-Pistons clash is scheduled to tip off at 7 p.m. ET (4 p.m. PT). The live telecast will be available on CHSN and FDSDET.
### Odds Overview
– **Moneyline:** Bulls (+114) vs. Pistons (-135)
– **Spread:** Bulls (+2.5 -110) vs. Pistons (-2.5 -110)
– **Total (O/U):** Bulls (Over 234.5 -108) vs. Pistons (Under 234.5 -112)
*Editor’s Note: The odds could change closer to the game. The odds listed are based on available information at the time of publication.*
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### Chicago Bulls vs. Detroit Pistons Preview
The Chicago Bulls and Detroit Pistons kicked off their 2025-2026 season with an entertaining matchup that was also their first meeting of the campaign. The Bulls’ dynamic duo of Josh Giddey and Nikola Vucevic led the charge with impressive double-doubles. Giddey put up 19 points and 11 assists, while Vucevic dominated the paint with 28 points and 14 rebounds.
Although the Pistons suffered a narrow 115-111 loss, there were plenty of positive takeaways. Cade Cunningham notched a 23-point, 10-assist double-double, and Isaiah Stewart made a huge impact off the bench with 20 points and 11 rebounds.
Heading into Wednesday’s game, Detroit looks much improved, boasting a seven-game winning streak with an average margin of victory of 11.0 points per game. The Bulls, meanwhile, are struggling through a three-game losing streak. They dropped both games on their recent road trip against Milwaukee and Cleveland, followed by a 121-117 home loss to the San Antonio Spurs on November 10.
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### Predicted Starting Lineups
**Chicago Bulls**
– G: Josh Giddey
– G: Ayo Dosunmu
– F: Isaac Okoro
– F: Matas Buzelis
– C: Nikola Vucevic
**Detroit Pistons**
– G: Cade Cunningham
– G: Duncan Robinson
– F: Javonte Green
– F: Ronald Holland II
– C: Jalen Duren
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### Chicago Bulls vs. Detroit Pistons Betting Tips
– **Josh Giddey Over/Under 7.5 assists:** Take the over
– **Cade Cunningham Over/Under 29.5 points:** Take the over
– **Jalen Duren Over/Under 13.5 rebounds:** Take the under
– **Nikola Vucevic Over/Under 18.5 points:** Take the under
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### Game Prediction
The Chicago Bulls are currently in a rough patch, facing a three-game losing streak heading into their matchup against the Pistons, who hold the best record in the Eastern Conference. Detroit’s roster runs deep, with several players beyond Cade Cunningham capable of taking over a game with strong scoring performances.
However, the Pistons will be dealing with a few injuries, as Ausar Thompson, Tobias Harris, and Isaiah Stewart are all expected to be out. This could give the Bulls a chance to keep things competitive. Despite this, Detroit should have enough firepower to secure the victory.
**Prediction:** Expect the Pistons to win by six points.
https://www.sportskeeda.com/basketball/news-chicago-bulls-vs-detroit-pistons-prediction-preview-nov-12-2025-26-nba-season
