Study shows big cause of autism, ADHD

**New Study Reveals How Inflammation Affects Brain Development in Children**

Scientists at the University of Maryland School of Medicine have made an important discovery about how the brain grows during childhood. Their research shows that inflammation — the body’s natural reaction to sickness or injury — can impact the development of certain brain cells. This groundbreaking finding may help explain why some children develop neurodevelopmental disorders such as autism or attention-deficit/hyperactivity disorder (ADHD).

### Understanding Neurodevelopmental Disorders

Neurodevelopmental disorders are conditions that affect how a child’s brain develops and functions. These disorders often begin early in life and typically last throughout a person’s lifetime. Children with these conditions may face challenges in learning, speaking, socializing, or managing their emotions. Common examples include autism spectrum disorder and ADHD.

### The Complexity of the Developing Brain

The human brain is incredibly complex. It starts forming early during pregnancy and continues to develop throughout childhood. The brain is made up of billions of neurons, which are cells that help us think, feel, move, and connect with others.

One vital part of the brain is the cerebellum. While it is well known for controlling movement — such as walking or writing — it also plays a role in thinking, language, emotions, and social interactions.

### How Inflammation Impacts Brain Cells

In this new study, researchers investigated how inflammation affects the brains of children. They examined brain tissue from children who had passed away due to illnesses that caused inflammation, such as infections or asthma. These were compared to brain samples from children who died in accidents and showed no signs of inflammation.

To analyze the brain cells in precise detail, scientists used a cutting-edge technique called single-cell genomics. This method allows researchers to study the characteristics of individual brain cells one by one.

### Key Findings: Golgi and Purkinje Neurons Affected

The study revealed that two special types of neurons in the cerebellum — Golgi neurons and Purkinje neurons — were impacted by inflammation.

– **Golgi neurons** help facilitate communication between other cells in the cerebellum.
– **Purkinje neurons** serve as a link between the cerebellum and other parts of the brain responsible for thinking and emotions.

In children who experienced inflammation, these neurons did not develop as they should. This abnormal development could help explain why some children who suffer from early sickness or inflammation later develop conditions such as autism or schizophrenia.

### Implications for the Future

This discovery marks a significant advancement in understanding how neurodevelopmental disorders may start. It opens new avenues for research and offers hope that future treatments could prevent or reduce the impact of these brain conditions before they begin.

### Supporting Mental Health Through Research

Neurodevelopmental disorders affect many children and their families deeply. Studies like this one provide crucial insights into the brain and pave the way for better care and support.

For those interested in mental health research, consider exploring the following studies:

– *Middle-aged women with no children may have increased risk of certain mental health issues.*
– *Scientific findings on the causes of mental illnesses induced by childhood abuse.*
– *Frequent painkiller use linked to mental health risks in specific populations.*
– *Common depression drugs may offer new treatments for bipolar disorder.*

### Publication Details

The full study detailing these findings was published in the journal *Science Translational Medicine*.

*Stay informed and support ongoing research to help children live healthier, happier lives.*
https://knowridge.com/2025/10/study-shows-big-cause-of-autism-adhd/

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